04) and on thalamic volume in patients with Expanded Disability Status Scale scores of <4.0 ( P =. 04) and those with disease duration of <5 years ( P =. White matter lesion volume showed an impact on subcortical gray matter volume in patients with relapsing-remitting MS ( P =. 03) independent of white matter lesion volume and T1 hypointensity volume. In our multiple regression model, intracortical lesion volume was the only predictor of thalamic volume ( R 2 = 0.4, b* = -0.28, P =. The presence of intracortical lesions was associated with a significant decrease of subcortical gray matter volume ( P =. 001), and higher Expanded Disability Status Scale scores ( P =. Patients with intracortical lesions were older ( P =. Age, MS duration, and the Expanded Disability Status Scale score were assessed. Volumes of white matter T1 hypointensities and subcortical gray matter, thalamus, caudate, putamen, and pallidum volumes were calculated using FreeSurfer. The volumes of intracortical lesions and white matter lesions were identified on double inversion recovery and FLAIR, respectively, by using 3D Slicer. Seventy-one patients with MS were included. We investigated the impact of intracortical lesions on the volumes of subcortical structures (especially the thalamus) compared with other lesions in MS. Recent studies showed thalamic atrophy in the early stages of MS.
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